General Information

  • ID:  hor003820
  • Uniprot ID:  P87352
  • Protein name:  Gamma-melanotropin-like segment
  • Gene name:  pomc
  • Organism:  Acipenser transmontanus (White sturgeon)
  • Family:  POMC family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Acipenser (genus), Acipenserini (tribe), Acipenserinae (subfamily), Acipenseridae (family), Acipenseroidei (suborder), Acipenseriformes (order), Chondrostei (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  NYVMSHFHWNTFGQRMNGTPGGS
  • Length:  23(75-97)
  • Propeptide:  MLHPVWGCVVAVMGVLWFYSSGVQSQCWEHSQCRDLASEANILECIQACKVDLSAESPLFPGNGHLQPTSEDIQNYVMSHFHWNTFGQRMNGTPGGSKREGASTALSVLLEALSQPRDEVERESEEEEGLQQHRRDDKRSYSMEHFRWGKPVGRKRRPVKVYPNGVEEESAESYPAEIRRDLSLKLDYPQGEELEEVFGGENDLLNLQKKDGSYKMNHFRWSGPPKDKRYGGFMKSWDERSQKPLLTLFKNVMIK
  • Signal peptide:  MLHPVWGCVVAVMGVLWFYSSGVQS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  [Corticotropin]: Stimulates the adrenal glands to release cortisol.; [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.; [Melanocyte-stimulating hormone beta]:
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P87352-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003820_AF2.pdbhor003820_ESM.pdb

Physical Information

Mass: 301845 Formula: C115H161N35O33S2
Absent amino acids: ACDEIKL Common amino acids: G
pI: 9.35 Basic residues: 3
Polar residues: 12 Hydrophobic residues: 4
Hydrophobicity: -85.65 Boman Index: -4099
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 12.61
Instability Index: 2508.7 Extinction Coefficient cystines: 6990
Absorbance 280nm: 317.73

Literature

  • PubMed ID:  9016801
  • Title:  Sturgeon Proopiomelanocortin Has a Remnant of Gamma-Melanotropin